The 11+ Benefits of Moringa Oleifera

Say Good Morning to Moringa 

Moringa oleifera (M. oleifera) has been used to treat various conditions and diseases, but only a few of the health claims have been studied scientifically. R

 
 

Basics

It is an angiosperm plant, native of the Indian subcontinent, where its various parts have been utilized throughout history as food and medicine. R

Moringa leaves have been reported to act as a hypocholesterolemic agent, thyroid hormone regulator, antidiabetic agent, antitumor agent and hypotensive agent. R R

In combination with cannabidiol, it has shown to be an anti-inflammatory, antioxidant, and anti-apoptotic. R

Benefits

1. Has Anti-Cancer Properties

 
 

The seeds of Moringa oleifera have immunosuppressive activity when taken in an ethanol extract. R

Glucomoringin extracted from Moringa was shown to have a growth inhibitory effect, probably due to NF-kB inhibition. R

It also induced apoptosis in human carcinoma cells, and were more pronounced in myeloma cells. R

Moringa showed prominent cytotoxicity to cancer cell lines and a significant hepatoprotective effect. R

It induced apoptosis of human liver carcinoma cells. R

It significantly inhibited the secretion of NO production and other inflammatory markers such as prostaglandin E2, TNF-alpha, IL-6, and IL-1β. R R

It induced the production of IL-10 in a dose-dependent manner. R

It suppressed the protein expression of inflammatory markers inducible NOS, COX-2, and NFkB p65. R

It lowered MMP-9 in CIR-induced rats. R

Moringa had antiproliferative effects on cancerious esophageal cells in esophageal cancer by increasing lipid peroxidation, DNA fragmentation, and induction of apoptosis. R

It extract exerts its cytotoxic effect in A549 cancer cells by affecting mitochondrial viability and inducing apoptosis in an ROS-dependent manner. R

2. High in Nutrients and Anti-Oxidants

 
 

Moringa leaf is a potential source of natural antioxidants. R R

It is high in vitamin A, vitamin, C, and vitamin E. R R

It is also high in beta-carotine, quercitin, and chlorogenic acid. R R R

The leaves are a rich source of essential amino acids such as methionine, cysteine, tryptophan, lysine, vitamins and minerals. R R

When used as a cream, Moringa protected the skin from aging by reducing ROS (reactive oxygen species). R

Moringa leaf extract is also used as a preservative to protect raw beef from oxidizing. R

3. Has Anti-inflammatory Properties

Sustained inflammation is believed to be involved with many chronic diseases. R R

In a dose-dependent manner, moringa exhibited antinociceptive activity (blocking the detection of a painful or injurious stimulus by sensory neurons). R

It prevented inflammation by reducing phosho-ERKp42/44 and p-selectin. R

Moringa attenuated expression of iNOS and IL-1β and production of nitric oxide and TNFα. R

4. Is an Anti-Diabetic

 
 

30 women took seven grams of moringa leaf powder every day for three months. It reduced fasting blood sugar levels by 13.5%. R

Adding 50 grams of Moringa leaves to a meal reduced the rise in blood sugar by 21%. R

Moringa-treated retinae showed marked prevention in the dilatation of retinal vessels suggesting that it may be useful in preventing diabetes induced retinal dysfunction. R

It has insulin-like antigenic epitopes, meaning it may possibly be useful in treating diabetes. R

Moringa may delay or prevent AGE-related diabetic complications. R

MO leaf powder capsules significantly increased insulin secretion in healthy subjects. R

5. Helps with Erectile Dysfunction

In rats, Moringa leaves Inhibited key enzymes linked to erectile dysfunction. R

6. Lowers Cholesterol

The leaves of Moringa oleifera have hypocholesterolemic (cholesterol lowering) activity. R

Therefore, it may be therapeutic in preventing cardiovascular diseases. R

In animals:

  • Rabbits fed Moringa showed a decrease in lipid profile of the liver, heart and aorta. R

7. Protects Against Arsenic Poisoning

 
 

Arsenic intoxication is associated with severe health hazards including dermatitis, hyperkeratosis, gangrene, and skin cancer. R R

Higher concentrations of arsenic causes oxidative stress, increased generation of reactive oxygen species and nitric oxide, inhibition of enzyme and mitochondrial function, and induction of several stress genes. R R

In animals:

  • Moringa leaves and seeds may protect against arsenic-induced oxidative stress R R R

8. Protects the Liver

 
 

Moringa seed protected the liver from oxidative stress induced by arsenic R

It prevented acetaminophen induced liver injury through restoration of glutathione level. R R

It may be beneficial in treating hyperlipidemia and ultrastructural changes in liver cells due to iron-deficiency. R

In rats, treatment with moringa extracts or silymarin appeared to enhance the recovery from hepatic damage induced by antitubercular drugs. R

Moringa normalizedelevated hepatic pyruvate carboxylase enzyme and regenerated damaged hepatocytes and pancreatic β cells via its antioxidant properties. R

9. Helps with Asthma

Treatment with the Moringa for 3 weeks produced significant improvement in forced vital capacity, forced expiratory volume in one second, and peak expiratory flow rate. R

Significant improvement was also observed in symptom score and severity of asthmatic attacks. R

10. Anti-Viral and Fights Pathogens

 
 

Treatment of G. pentaphyllum or M. oleifera leaf extracts with artesunate was able to increase the antimalarial activity by using low dose of artesunate. R

Moringa had antipyretic(fever reducing) activity in animal models. R

It enhancied the proliferation of lymphocytes and inducing NO from macrophages. R

It had antibacterial activity against various Gram positive and Gram negative bacterial pathogens. R

11. May Be Neuroprotective

Through an antioxidant mechanism, Moringa showed neuroprotection following spinal cord injury. R

Where To Get Moringa

 
 

Moringa in powder form

Moringa in capsule

Moringa as cream

As for dose: Moringa oleifera is genotoxic at supra-supplementation levels of 3,000 mg/kg b.wt. However, intake is safe at levels ≤ 1,000 mg/kg b.wt. R

Side Effects

Before M. oleifera leaf formulations can be recommended as "medication", it is necessary that the scientific basis of their efficacy, the therapeutic modalities of their administration and their possible side effects be more rigorously determined. R

Standardization of products is an issue. However, the results of published studies to date involving M. oleifera are very promising. R

A dose-dependent reduction of body weight gain was noted at the term of the sub-acute treatment with M. oleifera extract. R

More Research

  • Moringa, along with aloe vera, euphorbia species, citrullus colocynthis, and costus speciosus may be used in ameliorating MS symptoms. R
  • Moringa oleifera seeds inhibited  JAK/STAT signaling. R
  • MLAuNP significantly decreased Bcl-2, Hsp70, Skp2, Fbw7α, c-myc mRNA, and protein levels and activated alternate splicing with caspase-9a splice variant being significantly increased. R
  • Moringa induces apoptosis through p53 and Bax activation and Bcl-2 inhibition. R