The 4+ Benefits Of Peptide 6 (P6)

One Small Protein To Promote Neurogenesis

Peptide 6 is a small protein that can enhance neurogenesis and help with many neurocognitive disorders. 

 
 

Basics

Peptide 6 (P6) is a small molecule that is based off of ciliary neurotropic factor (CNTF), with neurogenic and neurotrophic properties in mouse models of Alzheimer's, traumatic brain injuries, autism spectrum disorders, and down syndrome. R

Benefits

1. Helps With Neurogenesis

 
 

In mice, P6 increases neurogenesis in the brain (partially through inhibiting LIF, which is known to inhibit neurogenesis). R

Hippocampal neuronal loss accompanies >80% of fatal tramautic brain injuries (TBI) and cell death in the hippocampus can be observed up to 12 months following TBI. R

In mice that had TBI, 30-day administration of P6 prevented neuronal loss in the hippocampus. R

2. Helps With Alzheimer's Disease

Neuronal loss in CA1 and parietal cortex are common problems with Alzheimer's Disease (AD), increasing tau and amyloid beta. R

In mice with TBI-induced tau and amyloid beta, P6 prevented neuronal loss in the CA1 and parietal cortex. R

It also helped restore dendritic and synaptic density in those areas (via Peptide 6's ability to inhibit LIF activity). R

In mice with AD, P6 restored cognition by enhancing neurogenesis and neuronal plasticity. R

In another study, cerebrolysin (CBL), P6 and 6A all potentiate neurogenesis in the mice with AβPP. R

3. Helps With Autism Spectrum Disorders

 
 

Autism spectrum disorders (ASD) is a neurodevelopmental disorder characterized clinically by impairments in social interaction and verbal and non-verbal communication skills as well as restricted interests and repetitive behavior. R

In rats that were given sera (blood) from ASD children, P6 was able to prevent cell death and oxidative stress. R

It also rescued rat pups from developmental delays that are normally caused by ASD children's sera. R

In these mice, P6 was able to increase social exploration, grooming, and vocaalization (such as USVs). R

P6 also increased blood levels of BDNF and CNTF, helping protect against neurodegeneration and neuroinflammation . R

4. Helps With Down Syndrome

Down syndrome (DS) is caused by the triplication of È240 proteincoding genes on chromosome 21 and is the most prevalent form of developmental disability. R

The DS brain exhibits degeneration of cortical neurons, profound dendritic and synaptic abnormalities, and a hypocellular hippocampus and cerebral cortex.

In mice with DS, P6 helped improve cognitive function and reduced memory impairment through increased hippocampal growth. R

Mechanism Of Action

P6 works similarly to CNTF, but is a much smaller protein and has less side effects. R

An even smaller version of P6 is Peptide 021 (P21). R

Adding an adamantylated glycine group to P6 to enhance its blood brain barrier (BBB) permeability makes P21. R

P6 inhibits leukemia inhibitory factor (LIF) activity and CNTF/JAK/STAT3 signaling. R

LIF is known to inhibit neurogenesis and promote self-renewal of the early, mostly gliagenic, progenitor cells. R

It also increases EGR-1 gene expression in the brain. R

It has a plasma half-life of over 6 hours. R

P6:

  • Easily crosses BBB R
  • Increases AMPA receptor expression R
  • Increases BDNF expression R
  • Increases CNTF expression R
  • Increases MAP2 expression R
  • Increases PSD95 expression R

Caveats

P6 is a research chemical and most studies on it has only been done in animal models. R

P6 doesn't appear to have the common side effects of CNTF, such as anorexia, skeletal muscle loss, hyperalgesia, severe cramps, and muscle pain. R

More Research

  • Peptide 6-treated I2NTF-CTF rats showed a significant increase in dendritic and synaptic density as reflected by increased expression of synapsin I, synaptophysin and MAP2, especially in the pyramidal neurons of CA1 and CA3 of the hippocampus. R