Gluten is NOT the Problem - it is ATIs

ATIs

ATIs make up no more than 4% of wheat proteins, but can trigger powerful immune reactions in the gut that can spread to other tissues in the body.

 
 
 
And now let's add ATIs into the picture. 

And now let's add ATIs into the picture

 

Celiac vs Gluten Intolerance

Non Celiac Gluten sensitivity was originally described in the 1980s and recently a “re-discovered” disorder characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food. R

What are ATIs?

Amylase trypsin inhibitors (ATIs) can drive intestinal inflammation via activation of toll-like receptor 4. They are found in gluten, such as wheat, barley, or rye ,which triggers small intestinal inflammation. R

ATIs may be prime candidates of severe forms of non-celiac gluten (wheat) sensitivity. R

ATIs are not classified as gluten proteins, but ATIs are found in grain endosperm along with the gluten proteins and usually co-fractionate with the gliadin fraction. R

How Do They Relate to Gluten?

 

Pour some gluten on me.

 

ATIs represent up to 4% of total wheat protein and are highly resistant to intestinal proteases. R

Specifically, gluten elicits and adaptive Th1-mediated immune response in people who have mutation in HLA-DQ2 ore HLA-DQ8.

ATIs engage the TLR4-MD2-CD14 complex, which will release proinflammatory cytokines in cells from celiac and nonceliac patients.

Therefore, ATI's may fuel inflammation and immune reactions in other intestinal and nonintestinal immune disorders.  R R

Gliadin

Omega gliadin proteins are one of the most allergenic components of wheat gluten. R

Wheat without omega gliadin proteins are being researched. R

What Helps?

I don't have an allergy to gluten, but do react to ATIs. When I travel, this is what I use, since it breaks down amylase and gluten proteins. 

More Research

  • Gluten free diets may have more toxic minerals in them like mercury. R