Tyrosine - An Amino Acid for Depression and Energy

Increase Motivation with Tyrosine

Tyrosine is an amino acid. It is used for the creation of L-DOPA, which then can get converted into catecholamines, like dopamine, noradrenaline and adrenaline. R


L-Tyrosine at physiological pH

L-Tyrosine at physiological pH


In the body, we usually start off with phenylalanine hydroxylase. Some people with genetic mutations can have PKU (phenylketonuria) and have too much phenylalanine build up in the blood. This can lead to mental retardation amongst other problems. R

BH4 has been shown to be helpful for PKU. This is because BH4 and B6 are cofactors in the conversion process of turning phenylanine into tyrosine, tyrosine into L-DOPA, and L-DOPA into catecholamines. R R


1. Helps with Attention and Cognition


Tyrosine is able to improve cognitive function. R

L- Tyrosine helped reduce symptoms of ADHD, when combined with Vitamin C, calcium citrate, B6, folate, L-Lysine, L-cysteine and selenium. R

Tyrosine can also help with cognitive switching, improving cognitive performance. R

It can also promote deep thinking. R

2. Can Induce Wakefulness

150mg/kg of L-tyrosine attenuated decreases in cognitive performance that was associated with sleep deprivation. R

3. May Alleviate Stress


Stress can deplete NA (noradrenaline) concentrations in neural tissue (particularly in the hypothalamus and brainstem containing the locus coeruleus). R

There are behavior alterations associated with NA depletion in animal studies, such as avoidance/escape, spontaneous motor activity, and aggressive behaviors. R R R

L-tyrosine supplementation can attenuate the development of these behaviors. R R R R

L-tyrosine protected against acute stress during a week-long combat training, although the study didn't show any improvements in mood. R

4. May Help Memory when Stressed

L-tryosine may reverse losses of memory induced by cold stress in humans. R

Although, another study showed no increase in cognitive function from baseline when tested in a 4°C room. R

In animals:

  • L-tryosine can increase NA in the hippocampus. This can prevent stress-induced reduction of NA in rats when subjected to cold stress. R

5. Protects Neurons from Aging


L-tyrosine helps the creation of catecholamines. Catecholamines may act as anti-oxidants in the brain and be neuroprotective. R

6. Inhibits Unwanted Tendencies

In a study to test wanted and unwanted taps, participants taking tyrosine were more efficient in inhibiting unwanted action tendencies. R

My Experience with Tyrosine

When I take tyrosine, I notice increased motivation, verbal fluency, and a sense of calmness in the world. I feel like I can take on any challenge with ease. I will take this a few times a month with BH4.

I notice the best effects at 500mg on an empty stomach right when I wake up. I notice nothing if I have eaten that day.

Where To Get It


I use L-Tyrosine from bulk supplements.

More Research

  • N-Acetyl-L-Tyrosine is a more soluble form of L-Tyrosine that is more heat stable. It is deacetylated in the kidneys. R
  • Some studies have shown chronic migraines can be from elevated plasma levels of tyrosine amongst other neurotransmitters. R
  • L-tyrosine does not appear to enahnce performance systemically. R